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PMCH

CANCER ATLAS

Gene description

 Pro-melanin-concentrating hormone

Protein class

 Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA046055
HPA061884

GENE INFORMATION

Gene name

 PMCH (HGNC Symbol)

Synonyms

 MCH

Description

 Pro-melanin-concentrating hormone (HGNC Symbol)

Entrez gene summary

 This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep. Pseudogenes of this gene have been identified on chromosome 5. [provided by RefSeq, Jul 2015]

Chromosome

 12

Cytoband

 q23.2

Chromosome location (bp)

 102196459 - 102197845

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183395 (version 83.38)

Entrez gene

 5367

UniProt

 P20382 (UniProt - Evidence at protein level)

neXtProt

 NX_P20382

Antibodypedia

 PMCH antibodies

PROTEIN BROWSER
PMCH-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PMCH-001
ENSP00000332225
ENST00000329406
P20382 [Direct mapping]
Pro-MCH Neuropeptide-glycine-glutamic acid Neuropeptide-glutamic acid-isoleucine Melanin-concentrating hormone
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   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0007631 [feeding behavior]
GO:0030154 [cell differentiation]
GO:0030354 [melanin-concentrating hormone activity]
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 165 aa
18.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.