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PMCH

GENERAL INFORMATION

Gene name

 PMCH

Gene description

 Pro-melanin-concentrating hormone

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node)
GTEx:Tissue enriched (hypothalamus)
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Hihgly expressed in neurons and neural processes in hypothalamus.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with external characterization data and GTEx RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA046055 , HPA061884
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Hypothalamus

Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 PMCH (HGNC Symbol)

Synonyms

 MCH

Description

 Pro-melanin-concentrating hormone (HGNC Symbol)

Entrez gene summary

 This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep. Pseudogenes of this gene have been identified on chromosome 5. [provided by RefSeq, Jul 2015]

Chromosome

 12

Cytoband

 q23.2

Chromosome location (bp)

 102196459 - 102197845

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183395 (version 83.38)

Entrez gene

 5367

UniProt

 P20382 (UniProt - Evidence at protein level)

neXtProt

 NX_P20382

Antibodypedia

 PMCH antibodies

PROTEIN BROWSER
PMCH-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PMCH-001
ENSP00000332225
ENST00000329406
P20382 [Direct mapping]
Pro-MCH Neuropeptide-glycine-glutamic acid Neuropeptide-glutamic acid-isoleucine Melanin-concentrating hormone
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   MEMSAT3 predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0007218 [neuropeptide signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007275 [multicellular organismal development]
GO:0007283 [spermatogenesis]
GO:0007631 [feeding behavior]
GO:0030154 [cell differentiation]
GO:0030354 [melanin-concentrating hormone activity]
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 165 aa
18.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.