Expression of LRIT3 in cancer - Summary

CANCER ATLAS

Gene description

Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA013454

GENE INFORMATION
Gene name	LRIT3 (HGNC Symbol)
Synonyms	CSNB1F, FIGLER4, FLJ44691
Description	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that has a fibronectin type III domain and a C-terminal transmembrane domain, as well as a leucine-rich repeat domain and immunoglobulin-like domain near the N-terminus. The encoded protein may regulate fibroblast growth factor receptors and affect the modification of these receptors, which are glycosylated differently in the Golgi and endoplasmic reticulum. Mutations in this gene are associated with congenital stationary night blindness, type 1F. [provided by RefSeq, May 2013]
Chromosome	4
Cytoband	q25
Chromosome location (bp)	109848202 - 109872315
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183423 (version 83.38)
Entrez gene	345193
UniProt	Q3SXY7 (UniProt - Evidence at protein level)
neXtProt	NX_Q3SXY7
Antibodypedia	LRIT3 antibodies

PROTEIN BROWSER

LRIT3-001	LRIT3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRIT3-001 ENSP00000328222 ENST00000327908	A0A0A0MR64 [Direct mapping] Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	496 aa 54.2 kDa	No	1
LRIT3-002 ENSP00000469759 ENST00000594814	Q3SXY7 [Direct mapping] Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007601 [visual perception] GO:0016021 [integral component of membrane] GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway] Show all	679 aa 74.8 kDa	Yes	1