Cell atlas - LRIT3 - The Human Protein Atlas

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LRIT3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria
	Nucleoplasm

Human cell
	Cytosol
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	LRIT3
Gene description	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol, mitochondria & nucleoplasm.
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Mitochondria (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA013454
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol, mitochondria & nucleoplasm.

Main location

Nucleoplasm (approved), Mitochondria (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA013454	A-431	Nucleoplasm
			Mitochondria
			Cytosol
	HPA013454	U-2 OS	Nucleoplasm
			Mitochondria
			Cytosol
	HPA013454	U-251 MG	Nucleoplasm
			Mitochondria
			Cytosol

GENE INFORMATION
Gene name	LRIT3 (HGNC Symbol)
Synonyms	CSNB1F, FIGLER4, FLJ44691
Description	Leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that has a fibronectin type III domain and a C-terminal transmembrane domain, as well as a leucine-rich repeat domain and immunoglobulin-like domain near the N-terminus. The encoded protein may regulate fibroblast growth factor receptors and affect the modification of these receptors, which are glycosylated differently in the Golgi and endoplasmic reticulum. Mutations in this gene are associated with congenital stationary night blindness, type 1F. [provided by RefSeq, May 2013]
Chromosome	4
Cytoband	q25
Chromosome location (bp)	109848202 - 109872315
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183423 (version 83.38)
Entrez gene	345193
UniProt	Q3SXY7 (UniProt - Evidence at protein level)
neXtProt	NX_Q3SXY7
Antibodypedia	LRIT3 antibodies

PROTEIN BROWSER

LRIT3-001	LRIT3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRIT3-001 ENSP00000328222 ENST00000327908	A0A0A0MR64 [Direct mapping] Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	496 aa 54.2 kDa	No	1
LRIT3-002 ENSP00000469759 ENST00000594814	Q3SXY7 [Direct mapping] Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0007601 [visual perception] GO:0016021 [integral component of membrane] GO:0040036 [regulation of fibroblast growth factor receptor signaling pathway] Show all	679 aa 74.8 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.