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Moderate to strong immunoreactivity was observed in skin cancers as well as a few cases of lung cancers. Remaining cancer cells were weakly stained or negative.
GENE INFORMATION
Gene name
MX2 (HGNC Symbol)
Synonyms
MXB
Description
MX dynamin-like GTPase 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]
P20592 [Direct mapping] Interferon-induced GTP-binding protein Mx2
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Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)