Tissue expression of MX2 - Summary - The Human Protein Atlas

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MX2

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MX2
Gene description	MX dynamin-like GTPase 2
Protein class	Plasma proteins Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (spleen)
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Mainly cytoplasmic expression in most tissues and in a subset of immune cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Uncertain based on 1 antibody. HPA030235
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	MX2 (HGNC Symbol)
Synonyms	MXB
Description	MX dynamin-like GTPase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	41361943 - 41409390
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183486 (version 83.38)
Entrez gene	4600
UniProt	P20592 (UniProt - Evidence at protein level)
neXtProt	NX_P20592
Antibodypedia	MX2 antibodies

PROTEIN BROWSER

MX2-001	MX2-006	MX2-007	MX2-008	MX2-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MX2-001 ENSP00000333657 ENST00000330714	P20592 [Direct mapping] Interferon-induced GTP-binding protein Mx2 Show all	Transporters Transporter channels and pores Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005643 [nuclear pore] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006952 [defense response] GO:0008152 [metabolic process] GO:0009615 [response to virus] GO:0015031 [protein transport] GO:0019221 [cytokine-mediated signaling pathway] GO:0035455 [response to interferon-alpha] GO:0046822 [regulation of nucleocytoplasmic transport] GO:0051028 [mRNA transport] GO:0051607 [defense response to virus] GO:0051726 [regulation of cell cycle] GO:0060337 [type I interferon signaling pathway] Show all	715 aa 82.1 kDa	No	0
MX2-006 ENSP00000393975 ENST00000436410	C9JZQ9 [Direct mapping] Interferon-induced GTP-binding protein Mx2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		129 aa 14.7 kDa	No	0
MX2-007 ENSP00000389256 ENST00000435611	C9JS04 [Direct mapping] Interferon-induced GTP-binding protein Mx2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 14.3 kDa	No	0
MX2-008 ENSP00000410188 ENST00000418103	C9JEL4 [Direct mapping] Interferon-induced GTP-binding protein Mx2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		134 aa 15.2 kDa	No	0
MX2-009 ENSP00000411179 ENST00000416447	C9J9T4 [Direct mapping] Interferon-induced GTP-binding protein Mx2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		14 aa 1.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.