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Weak to moderate cytoplasmic and nuclear immunoreactivity was exhibited in several papillary adenocarcinomas of thyroid, melanomas and ovarian cancers along with
a single case of basal cell carcinoma and seminoma. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
GKN2 (HGNC Symbol)
Synonyms
blottin, BRICD1B, GDDR, PRO813, TFIZ1, VLTI465
Description
Gastrokine 2 (HGNC Symbol)
Entrez gene summary
The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. [provided by RefSeq, Dec 2015]
