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GKN2

GENERAL INFORMATION

Gene name

 GKN2

Gene description

 Gastrokine 2

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (stomach)
GTEx:Tissue enriched (stomach)
FANTOM5:Tissue enriched (lung)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in gastric mucosa.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA057765
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (stomach)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (lung)

GENE INFORMATION

Gene name

 GKN2 (HGNC Symbol)

Synonyms

 blottin, BRICD1B, GDDR, PRO813, TFIZ1, VLTI465

Description

 Gastrokine 2 (HGNC Symbol)

Entrez gene summary

 The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. [provided by RefSeq, Dec 2015]

Chromosome

 2

Cytoband

 p13.3

Chromosome location (bp)

 68945232 - 68952970

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183607 (version 83.38)

Entrez gene

 200504

UniProt

 Q86XP6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86XP6

Antibodypedia

 GKN2 antibodies

PROTEIN BROWSER
GKN2-001
GKN2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GKN2-001
ENSP00000329292
ENST00000328895
Q86XP6 [Direct mapping]
Gastrokine-2
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005576 [extracellular region]
GO:0045178 [basal part of cell]
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 184 aa
20.5 kDa 		Yes 0
GKN2-003
ENSP00000428538
ENST00000481498
E5RHQ8 [Direct mapping]
Gastrokine-2
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 161 aa
18.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.