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Malignant cells were generally negative. Strong cytoplasmic positivity was observed in a few cases of malignant gliomas. Weak to moderate positivity was observed in malignant carcinoids and a few endometrial, breast and ovarian cancers.
GENE INFORMATION
Gene name
FAM19A1 (HGNC Symbol)
Synonyms
TAFA-1
Description
Family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 (HGNC Symbol)
Entrez gene summary
This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]
