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TUBA8

GENERAL INFORMATION

Gene name

 TUBA8

Gene description

 Tubulin, alpha 8

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (skeletal muscle, heart muscle, testis, cerebral cortex)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Tissue enhanced (skeletal muscle, testis)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 3 antibodies.
HPA043684 , HPA063394 , CAB046031
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, heart muscle, testis, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle, testis)

GENE INFORMATION

Gene name

 TUBA8 (HGNC Symbol)

Synonyms

 TUBAL2

Description

 Tubulin, alpha 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the alpha tubulin protein family. Alpha tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene are associated with polymicrogyria and optic nerve hypoplasia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Chromosome

 22

Cytoband

 q11.21

Chromosome location (bp)

 18110331 - 18146554

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000183785 (version 83.38)

Entrez gene

 51807

UniProt

 Q9NY65 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NY65

Antibodypedia

 TUBA8 antibodies

PROTEIN BROWSER
TUBA8-001
TUBA8-002
TUBA8-003
TUBA8-004
TUBA8-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBA8-001
ENSP00000333326
ENST00000330423
Q9NY65 [Direct mapping]
Tubulin alpha-8 chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
GO:0043234 [protein complex]
GO:0051258 [protein polymerization]
Show all
 449 aa
50.1 kDa 		No 0
TUBA8-002
ENSP00000318575
ENST00000316027
Q9NY65 [Direct mapping]
Tubulin alpha-8 chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
GO:0043234 [protein complex]
GO:0051258 [protein polymerization]
Show all
 383 aa
43 kDa 		No 0
TUBA8-003
ENSP00000412646
ENST00000416740
C9J2C0 [Direct mapping]
Tubulin alpha-8 chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
GO:0043234 [protein complex]
GO:0051258 [protein polymerization]
Show all
 467 aa
52 kDa 		No 0
TUBA8-004
ENSP00000407624
ENST00000426208
C9K0S6 [Direct mapping]
Tubulin alpha-8 chain
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 47 aa
5.3 kDa 		No 0
TUBA8-005
ENSP00000477306
ENST00000608634
V9GZ17 [Direct mapping]
Tubulin alpha-8 chain
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0043234 [protein complex]
GO:0051258 [protein polymerization]
Show all
 275 aa
31 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.