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Most malignant cells were negative. Fraction of cells in few basal cell carcinomas displayed strong cytoplasmic staining. Occasional malignant melanomas exhibited moderate cytoplasmic and nucleolar immunoreactivity.
GENE INFORMATION
Gene name
PNMA3 (HGNC Symbol)
Synonyms
MA3, MA5, MGC132756, MGC132758
Description
Paraneoplastic Ma antigen 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the paraneoplastic antigen MA (PNMA) family, which shares homology with retroviral Gag proteins. The PNMA antigens are highly expressed in the brain and also in a range of tumors associated with serious neurological phenotypes. PMID:16407312 reports the presence of a functional -1 ribosomal frameshift signal (consisting of a heptanucleotide shift motif followed 3' by a pseudoknot structure) in this gene, however, the frame-shifted product has not been characterized. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
