Fields »
ABOUT
HELP
BLOG
PNMA3

GENERAL INFORMATION

Gene name

 PNMA3

Gene description

 Paraneoplastic Ma antigen 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (epididymis, cerebral cortex, testis)
GTEx:Tissue enhanced (cerebral cortex, hypothalamus)
FANTOM5:Tissue enhanced (hippocampus, brain, epididymis)

Protein evidence

 Evidence at transcript level

Protein expression

 Expression in CNS and nucleoli in testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA047920
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (epididymis, cerebral cortex, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hippocampus, brain, epididymis)

GENE INFORMATION

Gene name

 PNMA3 (HGNC Symbol)

Synonyms

 MA3, MA5, MGC132756, MGC132758

Description

 Paraneoplastic Ma antigen 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the paraneoplastic antigen MA (PNMA) family, which shares homology with retroviral Gag proteins. The PNMA antigens are highly expressed in the brain and also in a range of tumors associated with serious neurological phenotypes. PMID:16407312 reports the presence of a functional -1 ribosomal frameshift signal (consisting of a heptanucleotide shift motif followed 3' by a pseudoknot structure) in this gene, however, the frame-shifted product has not been characterized. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 153056409 - 153060467

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000183837 (version 83.38)

Entrez gene

 29944

UniProt

 Q9UL41 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UL41

Antibodypedia

 PNMA3 antibodies

PROTEIN BROWSER
PNMA3-001
PNMA3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PNMA3-001
ENSP00000480719
ENST00000619635
Q9UL41 [Direct mapping]
Paraneoplastic antigen Ma3
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0005730 [nucleolus]
GO:0008270 [zinc ion binding]
GO:0043065 [positive regulation of apoptotic process]
Show all
 455 aa
51.5 kDa 		No 0
PNMA3-003
ENSP00000469445
ENST00000593810
Q9UL41 [Direct mapping]
Paraneoplastic antigen Ma3
Show all
Predicted intracellular proteins
Show all
GO:0003676 [nucleic acid binding]
GO:0005730 [nucleolus]
GO:0008270 [zinc ion binding]
GO:0043065 [positive regulation of apoptotic process]
Show all
 463 aa
52.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.