Cell atlas - COA3 - The Human Protein Atlas

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COA3

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	COA3
Gene description	Cytochrome c oxidase assembly factor 3
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA031966
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA031966	A-431	Mitochondria
	HPA031966	U-2 OS	Mitochondria
	HPA031966	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	COA3 (HGNC Symbol)
Synonyms	CCDC56, HSPC009, MITRAC12
Description	Cytochrome c oxidase assembly factor 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome c oxidase assembly factor family. Studies of a related gene in fly suggest that the encoded protein is localized to mitochondria and is essential for cytochrome c oxidase function. [provided by RefSeq, Nov 2012]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	42795147 - 42798704
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183978 (version 83.38)
Entrez gene	28958
UniProt	Q9Y2R0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2R0
Antibodypedia	COA3 antibodies

PROTEIN BROWSER

COA3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COA3-001 ENSP00000354762 ENST00000328434	Q9Y2R0 [Direct mapping] Cytochrome c oxidase assembly factor 3 homolog, mitochondrial A0A024R1X4 [Target identity:100%; Query identity:100%] HCG16955, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0031305 [integral component of mitochondrial inner membrane] GO:0033617 [mitochondrial respiratory chain complex IV assembly] GO:0070131 [positive regulation of mitochondrial translation] Show all	106 aa 11.7 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.