Cell atlas - TMPRSS2 - The Human Protein Atlas

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TMPRSS2

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Nucleoplasm

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	TMPRSS2
Gene description	Transmembrane protease, serine 2
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cell junctions. In addition localized to the nucleoplasm.
RNA cell category	Cell line enhanced (RT4, CACO-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cell Junctions (supported)
Additional location	In addition localized to the Nucleoplasm (uncertain)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA034493
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4, CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cell junctions. In addition localized to the nucleoplasm.

Main location

Cell Junctions (supported)

Additional location

Nucleoplasm (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA034493	CACO-2	Nucleoplasm
	HPA034493	CACO-2	Cell Junctions

GENE INFORMATION
Gene name	TMPRSS2 (HGNC Symbol)
Synonyms	PRSS10
Description	Transmembrane protease, serine 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Chromosome	21
Cytoband	q22.3
Chromosome location (bp)	41464551 - 41531116
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184012 (version 83.38)
Entrez gene	7113
UniProt	O15393 (UniProt - Evidence at protein level)
neXtProt	NX_O15393
Antibodypedia	TMPRSS2 antibodies

PROTEIN BROWSER

TMPRSS2-001	TMPRSS2-003	TMPRSS2-008	TMPRSS2-009	TMPRSS2-010	TMPRSS2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMPRSS2-001 ENSP00000330330 ENST00000332149	O15393 [Direct mapping] Transmembrane protease serine 2 Transmembrane protease serine 2 non-catalytic chain Transmembrane protease serine 2 catalytic chain Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016540 [protein autoprocessing] GO:0046598 [positive regulation of viral entry into host cell] GO:0070062 [extracellular exosome] Show all	492 aa 53.9 kDa	No	1
TMPRSS2-003 ENSP00000397846 ENST00000424093	C9J5Y1 [Direct mapping] Transmembrane protease serine 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	219 aa 23.9 kDa	No	1
TMPRSS2-008 ENSP00000389006 ENST00000454499	C9JKZ3 [Direct mapping] Transmembrane protease serine 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	489 aa 53.6 kDa	No	1
TMPRSS2-009 ENSP00000391216 ENST00000458356	O15393 [Direct mapping] Transmembrane protease serine 2 Transmembrane protease serine 2 non-catalytic chain Transmembrane protease serine 2 catalytic chain Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016540 [protein autoprocessing] GO:0046598 [positive regulation of viral entry into host cell] GO:0070062 [extracellular exosome] Show all	492 aa 53.9 kDa	No	1
TMPRSS2-010 ENSP00000391784 ENST00000455813	C9JB05 [Direct mapping] Transmembrane protease serine 2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		79 aa 8.5 kDa	No	0
TMPRSS2-201 ENSP00000381588 ENST00000398585	O15393 [Direct mapping] Transmembrane protease serine 2 Transmembrane protease serine 2 non-catalytic chain Transmembrane protease serine 2 catalytic chain Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016540 [protein autoprocessing] GO:0046598 [positive regulation of viral entry into host cell] GO:0070062 [extracellular exosome] Show all	529 aa 57.7 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.