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GDF3

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GENERAL INFORMATION

Gene name

 GDF3

Gene description

 Growth differentiation factor 3

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 GDF3

Synonyms

Description

 Growth differentiation factor 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 7689782 - 7695776

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184344 (version 83.38)

Entrez gene

 9573

UniProt

 Q9NR23 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NR23

Antibodypedia

 GDF3 antibodies

PROTEIN BROWSER
GDF3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GDF3-001
ENSP00000331745
ENST00000329913
Q9NR23 [Direct mapping]
Growth/differentiation factor 3
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   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001654 [eye development]
GO:0001701 [in utero embryonic development]
GO:0002021 [response to dietary excess]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0007492 [endoderm development]
GO:0007498 [mesoderm development]
GO:0008083 [growth factor activity]
GO:0010453 [regulation of cell fate commitment]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030509 [BMP signaling pathway]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030903 [notochord development]
GO:0032525 [somite rostral/caudal axis specification]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0045605 [negative regulation of epidermal cell differentiation]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0048468 [cell development]
GO:0048859 [formation of anatomical boundary]
GO:0060395 [SMAD protein signal transduction]
GO:0090009 [primitive streak formation]
Show all
 364 aa
41.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.