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PKP3

CANCER ATLAS

Gene description

 Plakophilin 3

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA062937
CAB012993

GENE INFORMATION

Gene name

 PKP3

Synonyms

Description

 Plakophilin 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 392614 - 404908

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184363 (version 83.38)

Entrez gene

 11187

UniProt

 Q9Y446 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y446

Antibodypedia

 PKP3 antibodies

PROTEIN BROWSER
PKP3-001
PKP3-002
PKP3-003
PKP3-004
PKP3-005
PKP3-006
PKP3-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PKP3-001
ENSP00000331678
ENST00000331563
Q9Y446 [Direct mapping]
Plakophilin-3
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002159 [desmosome assembly]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030057 [desmosome]
GO:0045294 [alpha-catenin binding]
GO:0050839 [cell adhesion molecule binding]
GO:0090002 [establishment of protein localization to plasma membrane]
Show all
 797 aa
87.1 kDa 		No 0
PKP3-002
ENSP00000434517
ENST00000534401
E9PQ15 [Direct mapping]
Plakophilin-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030057 [desmosome]
Show all
 247 aa
26.2 kDa 		No 0
PKP3-003
ENSP00000435383
ENST00000533249
E9PKC4 [Direct mapping]
Plakophilin-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030057 [desmosome]
Show all
 197 aa
21.1 kDa 		No 0
PKP3-004
ENSP00000435522
ENST00000527442
E9PJR7 [Direct mapping]
Plakophilin-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030057 [desmosome]
Show all
 120 aa
12.8 kDa 		No 0
PKP3-005
ENSP00000434110
ENST00000528036
E9PRW6 [Direct mapping]
Plakophilin-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030057 [desmosome]
Show all
 156 aa
16.8 kDa 		No 0
PKP3-006
ENSP00000435478
ENST00000531857
E9PK71 [Direct mapping]
Plakophilin-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030057 [desmosome]
Show all
 212 aa
22.3 kDa 		No 0
PKP3-010
ENSP00000436847
ENST00000525642
H0YEY5 [Direct mapping]
Plakophilin-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0016337 [single organismal cell-cell adhesion]
GO:0030057 [desmosome]
Show all
 115 aa
12.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.