Cell atlas - PKP3 - The Human Protein Atlas

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PKP3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PKP3
Gene description	Plakophilin 3
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cell junctions. In addition localized to the cytosol & nucleoplasm.
RNA cell category	Cell line enhanced (HaCaT, A-431, SK-BR-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Cell Junctions (validated)
Additional location	In addition localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. CAB012993 , HPA062937
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HaCaT, A-431, SK-BR-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cell junctions. In addition localized to the cytosol & nucleoplasm.

Main location

Cell Junctions (validated)

Additional location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
CAB012993	A-431	Cell Junctions
CAB012993	A-431	Cytosol
CAB012993	U-2 OS	No staining
CAB012993	U-251 MG	No staining
HPA062937	A-431	Nucleoplasm
HPA062937	A-431	Cell Junctions
HPA062937	HaCaT	Cell Junctions

GENE INFORMATION
Gene name	PKP3
Synonyms
Description	Plakophilin 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	392614 - 404908
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184363 (version 83.38)
Entrez gene	11187
UniProt	Q9Y446 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y446
Antibodypedia	PKP3 antibodies

PROTEIN BROWSER

PKP3-001	PKP3-002	PKP3-003	PKP3-004	PKP3-005	PKP3-006	PKP3-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PKP3-001 ENSP00000331678 ENST00000331563	Q9Y446 [Direct mapping] Plakophilin-3 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002159 [desmosome assembly] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0016337 [single organismal cell-cell adhesion] GO:0030057 [desmosome] GO:0045294 [alpha-catenin binding] GO:0050839 [cell adhesion molecule binding] GO:0090002 [establishment of protein localization to plasma membrane] Show all	797 aa 87.1 kDa	No	0
PKP3-002 ENSP00000434517 ENST00000534401	E9PQ15 [Direct mapping] Plakophilin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0016337 [single organismal cell-cell adhesion] GO:0030057 [desmosome] Show all	247 aa 26.2 kDa	No	0
PKP3-003 ENSP00000435383 ENST00000533249	E9PKC4 [Direct mapping] Plakophilin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0016337 [single organismal cell-cell adhesion] GO:0030057 [desmosome] Show all	197 aa 21.1 kDa	No	0
PKP3-004 ENSP00000435522 ENST00000527442	E9PJR7 [Direct mapping] Plakophilin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0016337 [single organismal cell-cell adhesion] GO:0030057 [desmosome] Show all	120 aa 12.8 kDa	No	0
PKP3-005 ENSP00000434110 ENST00000528036	E9PRW6 [Direct mapping] Plakophilin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0016337 [single organismal cell-cell adhesion] GO:0030057 [desmosome] Show all	156 aa 16.8 kDa	No	0
PKP3-006 ENSP00000435478 ENST00000531857	E9PK71 [Direct mapping] Plakophilin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0016337 [single organismal cell-cell adhesion] GO:0030057 [desmosome] Show all	212 aa 22.3 kDa	No	0
PKP3-010 ENSP00000436847 ENST00000525642	H0YEY5 [Direct mapping] Plakophilin-3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0016337 [single organismal cell-cell adhesion] GO:0030057 [desmosome] Show all	115 aa 12.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.