Expression of SS18L1 in cancer - Summary

CANCER ATLAS

Gene description

Synovial sarcoma translocation gene on chromosome 18-like 1

Protein class

Cancer-related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB011827

GENE INFORMATION
Gene name	SS18L1 (HGNC Symbol)
Synonyms	KIAA0693
Description	Synovial sarcoma translocation gene on chromosome 18-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a calcium-responsive transactivator which is an essential subunit of a neuron-specific chromatin-remodeling complex. The structure of this gene is similar to that of the SS18 gene. Mutations in this gene are involved in amyotrophic lateral sclerosis (ALS). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	62143795 - 62182484
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184402 (version 83.38)
Entrez gene	26039
UniProt	O75177 (UniProt - Evidence at protein level)
neXtProt	NX_O75177
Antibodypedia	SS18L1 antibodies

PROTEIN BROWSER

SS18L1-003	SS18L1-004	SS18L1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SS18L1-003 ENSP00000333012 ENST00000331758	O75177 [Direct mapping] Calcium-responsive transactivator Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0000780 [condensed nuclear chromosome, centromeric region] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0016358 [dendrite development] GO:0016568 [chromatin modification] GO:0016604 [nuclear body] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0050773 [regulation of dendrite development] GO:0050775 [positive regulation of dendrite morphogenesis] GO:0071565 [nBAF complex] Show all	396 aa 43 kDa	No	0
SS18L1-004 ENSP00000398634 ENST00000450482	Q9BR54 [Direct mapping] Calcium-responsive transactivator Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		128 aa 13.8 kDa	No	0
SS18L1-201 ENSP00000359885 ENST00000370848	O75177 [Direct mapping] Calcium-responsive transactivator Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0016568 [chromatin modification] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	314 aa 33.8 kDa	No	0