Cell atlas - SS18L1 - The Human Protein Atlas

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SS18L1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	SS18L1
Gene description	Synovial sarcoma translocation gene on chromosome 18-like 1
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. CAB011827 , HPA059046
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB011827	A-431	Nucleoplasm
	CAB011827	A-431	Cytosol
	CAB011827	U-2 OS	No staining
	HPA059046	HeLa	Nucleus
	HPA059046	RH-30	Nucleoplasm
	HPA059046	RH-30	Cytosol
	HPA059046	U-2 OS	Nucleoplasm
	HPA059046	U-2 OS	Cytosol

GENE INFORMATION
Gene name	SS18L1 (HGNC Symbol)
Synonyms	KIAA0693
Description	Synovial sarcoma translocation gene on chromosome 18-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a calcium-responsive transactivator which is an essential subunit of a neuron-specific chromatin-remodeling complex. The structure of this gene is similar to that of the SS18 gene. Mutations in this gene are involved in amyotrophic lateral sclerosis (ALS). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	62143795 - 62182484
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184402 (version 83.38)
Entrez gene	26039
UniProt	O75177 (UniProt - Evidence at protein level)
neXtProt	NX_O75177
Antibodypedia	SS18L1 antibodies

PROTEIN BROWSER

SS18L1-003	SS18L1-004	SS18L1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SS18L1-003 ENSP00000333012 ENST00000331758	O75177 [Direct mapping] Calcium-responsive transactivator Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0000780 [condensed nuclear chromosome, centromeric region] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0016358 [dendrite development] GO:0016568 [chromatin modification] GO:0016604 [nuclear body] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0050773 [regulation of dendrite development] GO:0050775 [positive regulation of dendrite morphogenesis] GO:0071565 [nBAF complex] Show all	396 aa 43 kDa	No	0
SS18L1-004 ENSP00000398634 ENST00000450482	Q9BR54 [Direct mapping] Calcium-responsive transactivator Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		128 aa 13.8 kDa	No	0
SS18L1-201 ENSP00000359885 ENST00000370848	O75177 [Direct mapping] Calcium-responsive transactivator Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0016568 [chromatin modification] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	314 aa 33.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.