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Most cancers showed moderate or strong granular cytoplasmic staining. Most cases of lymphomas and squamous cell carcinomas were weakly stained or negative.
Most cancers showed weak to moderate cytoplasmic positivity with additional nuclear immunoreactivity.
GENE INFORMATION
Gene name
TXNRD2 (HGNC Symbol)
Synonyms
TR, TR3, TRXR2
Description
Thioredoxin reductase 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0055114 [oxidation-reduction process]
Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000302 [response to reactive oxygen species] GO:0000305 [response to oxygen radical] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0045454 [cell redox homeostasis] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process]
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0055114 [oxidation-reduction process]
