Cell atlas - TXNRD2 - The Human Protein Atlas

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TXNRD2

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria

Human cell
	Cytosol
	Mitochondria

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GENERAL INFORMATION
Gene name	TXNRD2
Gene description	Thioredoxin reductase 2
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)
Additional location	In addition localized to the Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA003323
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the cytosol.

Main location

Mitochondria (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA003323	A-431	Mitochondria
	HPA003323	U-2 OS	Cytosol
	HPA003323	U-251 MG	No staining

GENE INFORMATION
Gene name	TXNRD2 (HGNC Symbol)
Synonyms	TR, TR3, TRXR2
Description	Thioredoxin reductase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the class I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein is a selenocysteine-containing flavoenzyme that maintains thioredoxins in a reduced state, thereby playing a key role in regulating the cellular redox environment. Mammals have three related thioredoxin reductases. This gene encodes a mitochondrial form important for scavenging of reactive oxygen species in mitochondria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2013]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	19875517 - 19941992
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184470 (version 83.38)
Entrez gene	10587
UniProt	Q9NNW7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NNW7
Antibodypedia	TXNRD2 antibodies

PROTEIN BROWSER

TXNRD2-001	TXNRD2-003	TXNRD2-004	TXNRD2-005	TXNRD2-006	TXNRD2-012	TXNRD2-016	TXNRD2-017	TXNRD2-018	TXNRD2-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TXNRD2-001 ENSP00000334451 ENST00000334363	E7EWK1 [Direct mapping] Thioredoxin reductase 2, mitochondrial Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0055114 [oxidation-reduction process] Show all	338 aa 36.3 kDa	No	0
TXNRD2-003 ENSP00000383365 ENST00000400521	Q9NNW7 [Direct mapping] Thioredoxin reductase 2, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000302 [response to reactive oxygen species] GO:0000305 [response to oxygen radical] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0045454 [cell redox homeostasis] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	524 aa 56.5 kDa	No	0
TXNRD2-004 ENSP00000383362 ENST00000400518	E7ENA2 [Direct mapping] Thioredoxin reductase 2, mitochondrial Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005623 [cell] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0045454 [cell redox homeostasis] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	494 aa 53.6 kDa	No	0
TXNRD2-005 ENSP00000485543 ENST00000491939	A0A096LPD9 [Direct mapping] Thioredoxin reductase 2, mitochondrial Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0055114 [oxidation-reduction process] Show all	306 aa 33.2 kDa	No	0
TXNRD2-006 ENSP00000383369 ENST00000400525	D3YTF8 [Direct mapping] Thioredoxin reductase 2, mitochondrial Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005623 [cell] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0045454 [cell redox homeostasis] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	501 aa 54.3 kDa	No	0
TXNRD2-012 ENSP00000383363 ENST00000400519	D3YTF9 [Direct mapping] Thioredoxin reductase 2, mitochondrial Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005623 [cell] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0045454 [cell redox homeostasis] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	523 aa 56.4 kDa	No	0
TXNRD2-016 ENSP00000485290 ENST00000475995	A0A096LNY7 [Direct mapping] Thioredoxin reductase 2, mitochondrial Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	171 aa 18.3 kDa	No	0
TXNRD2-017 ENSP00000485603 ENST00000462330	A0A096LPH4 [Direct mapping] Thioredoxin reductase 2, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0016491 [oxidoreductase activity] GO:0045454 [cell redox homeostasis] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	165 aa 17.9 kDa	No	0
TXNRD2-018 ENSP00000485499 ENST00000485358	A0A096LPB7 [Direct mapping] Thioredoxin reductase 2, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005623 [cell] GO:0016491 [oxidoreductase activity] GO:0045454 [cell redox homeostasis] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	180 aa 19.4 kDa	Yes	0
TXNRD2-020 ENSP00000485128 ENST00000542719	A0A096LNN4 [Direct mapping] Thioredoxin reductase 2, mitochondrial Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005623 [cell] GO:0016491 [oxidoreductase activity] GO:0045454 [cell redox homeostasis] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	428 aa 46.8 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.