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Gliomas, most liver cancers along with several lymphomas and prostate cancers showed moderate cytoplasmic positivity. Remaining cancer cells were in general weakly stained or negative.
Most cancer tissues were negative. Liver, urothelial cancers and several gliomas showed weak to moderate cytoplasmic immunoreactivity.
GENE INFORMATION
Gene name
PROS1 (HGNC Symbol)
Synonyms
PROS
Description
Protein S (alpha) (HGNC Symbol)
Entrez gene summary
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
P07225 [Direct mapping] Vitamin K-dependent protein S
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
