Cell atlas - PROS1 - The Human Protein Atlas

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PROS1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	PROS1
Gene description	Protein S (alpha)
Protein class	Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (SK-MEL-30)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-MEL-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	PROS1 (HGNC Symbol)
Synonyms	PROS
Description	Protein S (alpha) (HGNC Symbol)
Entrez gene summary	This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]
Chromosome	3
Cytoband	q11.1
Chromosome location (bp)	93873033 - 93974066
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184500 (version 83.38)
Entrez gene	5627
UniProt	P07225 (UniProt - Evidence at protein level)
neXtProt	NX_P07225
Antibodypedia	PROS1 antibodies

PROTEIN BROWSER

PROS1-001	PROS1-002	PROS1-003	PROS1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PROS1-001 ENSP00000377783 ENST00000394236	P07225 [Direct mapping] Vitamin K-dependent protein S Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002576 [platelet degranulation] GO:0004866 [endopeptidase inhibitor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005789 [endoplasmic reticulum membrane] GO:0005796 [Golgi lumen] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0010951 [negative regulation of endopeptidase activity] GO:0017187 [peptidyl-glutamic acid carboxylation] GO:0030168 [platelet activation] GO:0030449 [regulation of complement activation] GO:0031093 [platelet alpha granule lumen] GO:0032403 [protein complex binding] GO:0032496 [response to lipopolysaccharide] GO:0042730 [fibrinolysis] GO:0043234 [protein complex] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045087 [innate immune response] GO:0050766 [positive regulation of phagocytosis] GO:0050900 [leukocyte migration] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	676 aa 75.1 kDa	Yes	0
PROS1-002 ENSP00000385794 ENST00000407433	G5E9F8 [Direct mapping] Protein S (Alpha), isoform CRA_b; Vitamin K-dependent protein S Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	545 aa 60.4 kDa	No	0
PROS1-003 ENSP00000330021 ENST00000348974	H7BXT0 [Direct mapping] Vitamin K-dependent protein S Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0016021 [integral component of membrane] Show all	231 aa 25.9 kDa	Yes	1
PROS1-004 ENSP00000419616 ENST00000472684	C9K0R0 [Direct mapping] Vitamin K-dependent protein S Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	56 aa 6.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.