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APOBR

GENERAL INFORMATION

Gene name

 APOBR

Gene description

 Apolipoprotein B receptor

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (spleen)
GTEx:Tissue enhanced (spleen)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in macrophages including Hofbauer, Kupffer and Langerhans cells as well as peripheral leukocytes, cells in red pulp of spleen and glandular cells of large intestine.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA041667 , HPA042093
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 APOBR (HGNC Symbol)

Synonyms

 APOB100R, APOB48R

Description

 Apolipoprotein B receptor (HGNC Symbol)

Entrez gene summary

 Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 p12.1

Chromosome location (bp)

 28494649 - 28498970

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184730 (version 83.38)

Entrez gene

 55911

UniProt

 Q0VD83 (UniProt - Evidence at protein level)

neXtProt

 NX_Q0VD83

Antibodypedia

 APOBR antibodies

PROTEIN BROWSER
APOBR-001
APOBR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APOBR-001
ENSP00000457539
ENST00000564831
Q0VD83 [Direct mapping]
Apolipoprotein B receptor
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0006641 [triglyceride metabolic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0008203 [cholesterol metabolic process]
GO:0016020 [membrane]
GO:0030229 [very-low-density lipoprotein particle receptor activity]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034362 [low-density lipoprotein particle]
GO:0042627 [chylomicron]
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 1097 aa
115.6 kDa 		No 0
APOBR-201
ENSP00000416094
ENST00000431282
Q0VD83 [Direct mapping]
Apolipoprotein B receptor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0006641 [triglyceride metabolic process]
GO:0006869 [lipid transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0008203 [cholesterol metabolic process]
GO:0016020 [membrane]
GO:0030229 [very-low-density lipoprotein particle receptor activity]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034362 [low-density lipoprotein particle]
GO:0042627 [chylomicron]
Show all
 1088 aa
114.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.