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SRY

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GENERAL INFORMATION

Gene name

 SRY

Gene description

 Sex determining region Y

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (hTCEpi, RT4)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (hTCEpi, RT4)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SRY (HGNC Symbol)

Synonyms

 TDF

Description

 Sex determining region Y (HGNC Symbol)

Entrez gene summary

 This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]

Chromosome

 Y

Cytoband

 p11.2

Chromosome location (bp)

 2786855 - 2787699

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184895 (version 83.38)

Entrez gene

 6736

UniProt

 Q05066 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05066

Antibodypedia

 SRY antibodies

PROTEIN BROWSER
SRY-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRY-001
ENSP00000372547
ENST00000383070
Q05066 [Direct mapping]
Sex-determining region Y protein
A7WPU8 [Target identity:100%; Query identity:100%]
Sex-determining region Y protein
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007530 [sex determination]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0008584 [male gonad development]
GO:0010629 [negative regulation of gene expression]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030238 [male sex determination]
GO:0044798 [nuclear transcription factor complex]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:2000020 [positive regulation of male gonad development]
Show all
 204 aa
23.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.