Tissue expression of SRY - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SRY
Gene description	Sex determining region Y
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis, skin)
GTEx:	Tissue enhanced (testis, skin)
FANTOM5:	Not detected

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis, skin)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis, skin)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	SRY (HGNC Symbol)
Synonyms	TDF
Description	Sex determining region Y (HGNC Symbol)
Entrez gene summary	This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]
Chromosome	Y
Cytoband	p11.2
Chromosome location (bp)	2786855 - 2787699
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184895 (version 83.38)
Entrez gene	6736
UniProt	Q05066 (UniProt - Evidence at protein level)
neXtProt	NX_Q05066
Antibodypedia	SRY antibodies

PROTEIN BROWSER

SRY-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SRY-001 ENSP00000372547 ENST00000383070	Q05066 [Direct mapping] Sex-determining region Y protein A7WPU8 [Target identity:100%; Query identity:100%] Sex-determining region Y protein Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0007530 [sex determination] GO:0008134 [transcription factor binding] GO:0008301 [DNA binding, bending] GO:0008584 [male gonad development] GO:0010629 [negative regulation of gene expression] GO:0016607 [nuclear speck] GO:0030154 [cell differentiation] GO:0030238 [male sex determination] GO:0044798 [nuclear transcription factor complex] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046982 [protein heterodimerization activity] GO:2000020 [positive regulation of male gonad development] Show all	204 aa 23.9 kDa	No	0