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SUMO3

GENERAL INFORMATION

Gene name

 SUMO3

Gene description

 Small ubiquitin-like modifier 3

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA042123 , HPA048064 , CAB012180
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SUMO3 (HGNC Symbol)

Synonyms

 SMT3A, SMT3H1

Description

 Small ubiquitin-like modifier 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 44805617 - 44818779

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184900 (version 83.38)

Entrez gene

 6612

UniProt

 P55854 (UniProt - Evidence at protein level)

neXtProt

 NX_P55854

Antibodypedia

 SUMO3 antibodies

PROTEIN BROWSER
SUMO3-001
SUMO3-002
SUMO3-005
SUMO3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SUMO3-001
ENSP00000330343
ENST00000332859
P55854 [Direct mapping]
Small ubiquitin-related modifier 3
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000776 [kinetochore]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0031386 [protein tag]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
GO:0070911 [global genome nucleotide-excision repair]
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 103 aa
11.6 kDa 		No 0
SUMO3-002
ENSP00000380995
ENST00000397898
A8MUA9 [Direct mapping]
SMT3 suppressor of mif two 3 homolog 3 (Yeast), isoform CRA_d; Small ubiquitin-related modifier 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0016925 [protein sumoylation]
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 135 aa
15.3 kDa 		No 0
SUMO3-005
ENSP00000380990
ENST00000397893
A8MU27 [Direct mapping]
Small ubiquitin-related modifier 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0016925 [protein sumoylation]
Show all
 147 aa
17 kDa 		No 0
SUMO3-201
ENSP00000409666
ENST00000411651
P55854 [Direct mapping]
Small ubiquitin-related modifier 3
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   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000776 [kinetochore]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0016925 [protein sumoylation]
GO:0019789 [SUMO transferase activity]
GO:0031386 [protein tag]
GO:0034504 [protein localization to nucleus]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0070062 [extracellular exosome]
GO:0070911 [global genome nucleotide-excision repair]
GO:2000060 [positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 141 aa
15.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.