Expression of IMMP2L in cancer - Summary

CANCER ATLAS

Gene description

Inner mitochondrial membrane peptidase subunit 2

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026711

GENE INFORMATION
Gene name	IMMP2L (HGNC Symbol)
Synonyms	IMMP2L-IT1, IMP2
Description	Inner mitochondrial membrane peptidase subunit 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011]
Chromosome	7
Cytoband	q31.1
Chromosome location (bp)	110663051 - 111562517
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184903 (version 83.38)
Entrez gene	83943
UniProt	Q96T52 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96T52
Antibodypedia	IMMP2L antibodies

PROTEIN BROWSER

IMMP2L-001	IMMP2L-002	IMMP2L-003	IMMP2L-005	IMMP2L-006	IMMP2L-008	IMMP2L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IMMP2L-001 ENSP00000384966 ENST00000405709	Q96T52 [Direct mapping] Mitochondrial inner membrane protease subunit 2 A4D0S9 [Target identity:100%; Query identity:100%] Mitochondrial inner membrane protease subunit 2 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001541 [ovarian follicle development] GO:0005739 [mitochondrion] GO:0006508 [proteolysis] GO:0006627 [protein processing involved in protein targeting to mitochondrion] GO:0006801 [superoxide metabolic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0007283 [spermatogenesis] GO:0007420 [brain development] GO:0008015 [blood circulation] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0030728 [ovulation] GO:0033108 [mitochondrial respiratory chain complex assembly] GO:0042720 [mitochondrial inner membrane peptidase complex] GO:0061300 [cerebellum vasculature development] Show all	175 aa 19.7 kDa	No	1
IMMP2L-002 ENSP00000329553 ENST00000331762	Q96T52 [Direct mapping] Mitochondrial inner membrane protease subunit 2 A4D0S9 [Target identity:100%; Query identity:100%] Mitochondrial inner membrane protease subunit 2 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0006627 [protein processing involved in protein targeting to mitochondrion] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042720 [mitochondrial inner membrane peptidase complex] Show all	175 aa 19.7 kDa	No	1
IMMP2L-003 ENSP00000399353 ENST00000452895	Q96T52 [Direct mapping] Mitochondrial inner membrane protease subunit 2 A4D0S9 [Target identity:100%; Query identity:100%] Mitochondrial inner membrane protease subunit 2 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0006627 [protein processing involved in protein targeting to mitochondrion] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042720 [mitochondrial inner membrane peptidase complex] Show all	175 aa 19.7 kDa	No	1
IMMP2L-005 ENSP00000388327 ENST00000447215	Q96T52 [Direct mapping] Mitochondrial inner membrane protease subunit 2 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0006627 [protein processing involved in protein targeting to mitochondrion] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042720 [mitochondrial inner membrane peptidase complex] Show all	110 aa 12.3 kDa	No	1
IMMP2L-006 ENSP00000407402 ENST00000452753	C9JVB0 [Direct mapping] Mitochondrial inner membrane protease subunit 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] Show all	79 aa 8.7 kDa	No	0
IMMP2L-008 ENSP00000402824 ENST00000450877	C9JQE1 [Direct mapping] Mitochondrial inner membrane protease subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0016021 [integral component of membrane] Show all	157 aa 18.1 kDa	No	0
IMMP2L-201 ENSP00000394387 ENST00000437687	A0A0C4DG32 [Direct mapping] Mitochondrial inner membrane protease subunit 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] Show all	80 aa 8.8 kDa	No	0