Tissue expression of IMMP2L - Summary - The Human Protein Atlas

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IMMP2L

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	IMMP2L
Gene description	Inner mitochondrial membrane peptidase subunit 2
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA026711
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	IMMP2L (HGNC Symbol)
Synonyms	IMMP2L-IT1, IMP2
Description	Inner mitochondrial membrane peptidase subunit 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011]
Chromosome	7
Cytoband	q31.1
Chromosome location (bp)	110663051 - 111562517
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184903 (version 83.38)
Entrez gene	83943
UniProt	Q96T52 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96T52
Antibodypedia	IMMP2L antibodies

PROTEIN BROWSER

IMMP2L-001	IMMP2L-002	IMMP2L-003	IMMP2L-005	IMMP2L-006	IMMP2L-008	IMMP2L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IMMP2L-001 ENSP00000384966 ENST00000405709	Q96T52 [Direct mapping] Mitochondrial inner membrane protease subunit 2 A4D0S9 [Target identity:100%; Query identity:100%] Mitochondrial inner membrane protease subunit 2 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001541 [ovarian follicle development] GO:0005739 [mitochondrion] GO:0006508 [proteolysis] GO:0006627 [protein processing involved in protein targeting to mitochondrion] GO:0006801 [superoxide metabolic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0007283 [spermatogenesis] GO:0007420 [brain development] GO:0008015 [blood circulation] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0030728 [ovulation] GO:0033108 [mitochondrial respiratory chain complex assembly] GO:0042720 [mitochondrial inner membrane peptidase complex] GO:0061300 [cerebellum vasculature development] Show all	175 aa 19.7 kDa	No	1
IMMP2L-002 ENSP00000329553 ENST00000331762	Q96T52 [Direct mapping] Mitochondrial inner membrane protease subunit 2 A4D0S9 [Target identity:100%; Query identity:100%] Mitochondrial inner membrane protease subunit 2 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0006627 [protein processing involved in protein targeting to mitochondrion] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042720 [mitochondrial inner membrane peptidase complex] Show all	175 aa 19.7 kDa	No	1
IMMP2L-003 ENSP00000399353 ENST00000452895	Q96T52 [Direct mapping] Mitochondrial inner membrane protease subunit 2 A4D0S9 [Target identity:100%; Query identity:100%] Mitochondrial inner membrane protease subunit 2 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0006627 [protein processing involved in protein targeting to mitochondrion] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042720 [mitochondrial inner membrane peptidase complex] Show all	175 aa 19.7 kDa	No	1
IMMP2L-005 ENSP00000388327 ENST00000447215	Q96T52 [Direct mapping] Mitochondrial inner membrane protease subunit 2 Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0006627 [protein processing involved in protein targeting to mitochondrion] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042720 [mitochondrial inner membrane peptidase complex] Show all	110 aa 12.3 kDa	No	1
IMMP2L-006 ENSP00000407402 ENST00000452753	C9JVB0 [Direct mapping] Mitochondrial inner membrane protease subunit 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] Show all	79 aa 8.7 kDa	No	0
IMMP2L-008 ENSP00000402824 ENST00000450877	C9JQE1 [Direct mapping] Mitochondrial inner membrane protease subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0016021 [integral component of membrane] Show all	157 aa 18.1 kDa	No	0
IMMP2L-201 ENSP00000394387 ENST00000437687	A0A0C4DG32 [Direct mapping] Mitochondrial inner membrane protease subunit 2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0016020 [membrane] Show all	80 aa 8.8 kDa	No	0

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