Expression of SGCZ in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Sarcoglycan, zeta

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA017585

GENE INFORMATION
Gene name	SGCZ (HGNC Symbol)
Synonyms	ZSG1
Description	Sarcoglycan, zeta (HGNC Symbol)
Entrez gene summary	The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extra-cellular matrix. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p22
Chromosome location (bp)	14089864 - 15238339
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000185053 (version 83.38)
Entrez gene	137868
UniProt	Q96LD1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96LD1
Antibodypedia	SGCZ antibodies

PROTEIN BROWSER

SGCZ-001	SGCZ-002	SGCZ-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SGCZ-001 ENSP00000371512 ENST00000382080	Q96LD1 [Direct mapping] Zeta-sarcoglycan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0007517 [muscle organ development] GO:0016012 [sarcoglycan complex] GO:0016021 [integral component of membrane] GO:0042383 [sarcolemma] GO:0046716 [muscle cell cellular homeostasis] GO:0048738 [cardiac muscle tissue development] GO:0055001 [muscle cell development] GO:0060047 [heart contraction] GO:0061024 [membrane organization] Show all	312 aa 34.5 kDa	No	1
SGCZ-002 ENSP00000405224 ENST00000421524	Q08AT0 [Direct mapping] SGCZ protein; Zeta-sarcoglycan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0007517 [muscle organ development] GO:0016012 [sarcoglycan complex] GO:0016021 [integral component of membrane] GO:0042383 [sarcolemma] GO:0048738 [cardiac muscle tissue development] GO:0060047 [heart contraction] Show all	265 aa 29.1 kDa	No	1
SGCZ-201 ENSP00000481839 ENST00000613692	A0A087WYI4 [Direct mapping] Zeta-sarcoglycan Show all	Predicted intracellular proteins Show all	GO:0007517 [muscle organ development] GO:0016012 [sarcoglycan complex] GO:0016021 [integral component of membrane] GO:0042383 [sarcolemma] GO:0048738 [cardiac muscle tissue development] GO:0060047 [heart contraction] Show all	181 aa 19.2 kDa	No	0