Tissue expression of SGCZ - Summary - The Human Protein Atlas

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SGCZ

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SGCZ
Gene description	Sarcoglycan, zeta
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (ovary, cerebral cortex)
GTEx:	Not detected
FANTOM5:	Tissue enhanced (cerebellum, pituitary gland, caudate)

Protein evidence

Evidence at transcript level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results.
Reliability score	Uncertain based on 1 antibody. HPA017585
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

Skeletal muscle

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (ovary, cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Not detected
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, pituitary gland, caudate)

GENE INFORMATION
Gene name	SGCZ (HGNC Symbol)
Synonyms	ZSG1
Description	Sarcoglycan, zeta (HGNC Symbol)
Entrez gene summary	The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the dystrophin-associated glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extra-cellular matrix. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p22
Chromosome location (bp)	14089864 - 15238339
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000185053 (version 83.38)
Entrez gene	137868
UniProt	Q96LD1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96LD1
Antibodypedia	SGCZ antibodies

PROTEIN BROWSER

SGCZ-001	SGCZ-002	SGCZ-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SGCZ-001 ENSP00000371512 ENST00000382080	Q96LD1 [Direct mapping] Zeta-sarcoglycan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0007517 [muscle organ development] GO:0016012 [sarcoglycan complex] GO:0016021 [integral component of membrane] GO:0042383 [sarcolemma] GO:0046716 [muscle cell cellular homeostasis] GO:0048738 [cardiac muscle tissue development] GO:0055001 [muscle cell development] GO:0060047 [heart contraction] GO:0061024 [membrane organization] Show all	312 aa 34.5 kDa	No	1
SGCZ-002 ENSP00000405224 ENST00000421524	Q08AT0 [Direct mapping] SGCZ protein; Zeta-sarcoglycan Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0007517 [muscle organ development] GO:0016012 [sarcoglycan complex] GO:0016021 [integral component of membrane] GO:0042383 [sarcolemma] GO:0048738 [cardiac muscle tissue development] GO:0060047 [heart contraction] Show all	265 aa 29.1 kDa	No	1
SGCZ-201 ENSP00000481839 ENST00000613692	A0A087WYI4 [Direct mapping] Zeta-sarcoglycan Show all	Predicted intracellular proteins Show all	GO:0007517 [muscle organ development] GO:0016012 [sarcoglycan complex] GO:0016021 [integral component of membrane] GO:0042383 [sarcolemma] GO:0048738 [cardiac muscle tissue development] GO:0060047 [heart contraction] Show all	181 aa 19.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.