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GENE INFORMATION
Gene name
PURA (HGNC Symbol)
Synonyms
PUR-ALPHA, PUR1, PURALPHA
Description
Purine-rich element binding protein A (HGNC Symbol)
Entrez gene summary
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Q00577 [Direct mapping] Transcriptional activator protein Pur-alpha
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Predicted intracellular proteins Plasma proteins Transcription factors Yet undefined DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000784 [nuclear chromosome, telomeric region] GO:0000900 [translation repressor activity, nucleic acid binding] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003691 [double-stranded telomeric DNA binding] GO:0003697 [single-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005662 [DNA replication factor A complex] GO:0005737 [cytoplasm] GO:0006268 [DNA unwinding involved in DNA replication] GO:0006270 [DNA replication initiation] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0017148 [negative regulation of translation] GO:0030154 [cell differentiation] GO:0030425 [dendrite] GO:0032422 [purine-rich negative regulatory element binding] GO:0043025 [neuronal cell body] GO:0044822 [poly(A) RNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046332 [SMAD binding]
