Tissue expression of PURA - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PURA
Gene description	Purine-rich element binding protein A
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PURA (HGNC Symbol)
Synonyms	PUR-ALPHA, PUR1, PURALPHA
Description	Purine-rich element binding protein A (HGNC Symbol)
Entrez gene summary	This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	140107777 - 140125619
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185129 (version 83.38)
Entrez gene	5813
UniProt	Q00577 (UniProt - Evidence at protein level)
neXtProt	NX_Q00577
Antibodypedia	PURA antibodies

PROTEIN BROWSER

PURA-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PURA-001 ENSP00000332706 ENST00000331327	Q00577 [Direct mapping] Transcriptional activator protein Pur-alpha Show all	Predicted intracellular proteins Plasma proteins Transcription factors Yet undefined DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000784 [nuclear chromosome, telomeric region] GO:0000900 [translation repressor activity, nucleic acid binding] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003691 [double-stranded telomeric DNA binding] GO:0003697 [single-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005662 [DNA replication factor A complex] GO:0005737 [cytoplasm] GO:0006268 [DNA unwinding involved in DNA replication] GO:0006270 [DNA replication initiation] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0017148 [negative regulation of translation] GO:0030154 [cell differentiation] GO:0030425 [dendrite] GO:0032422 [purine-rich negative regulatory element binding] GO:0043025 [neuronal cell body] GO:0044822 [poly(A) RNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046332 [SMAD binding] Show all	322 aa 34.9 kDa	No	0