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SCN10A

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GENERAL INFORMATION

Gene name

 SCN10A

Gene description

 Sodium channel, voltage gated, type X alpha subunit

Protein class

 Disease related genes
FDA approved drug targets
Plasma proteins
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 SCN10A (HGNC Symbol)

Synonyms

 hPN3, Nav1.8, PN3, SNS

Description

 Sodium channel, voltage gated, type X alpha subunit (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Chromosome

 3

Cytoband

 p22.2

Chromosome location (bp)

 38696802 - 38794010

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185313 (version 83.38)

Entrez gene

 6336

UniProt

 Q9Y5Y9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5Y9

Antibodypedia

 SCN10A antibodies

PROTEIN BROWSER
SCN10A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCN10A-001
ENSP00000390600
ENST00000449082
Q9Y5Y9 [Direct mapping]
Sodium channel protein type 10 subunit alpha
Show all
Voltage-gated ion channels
   Voltage-Gated Sodium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001518 [voltage-gated sodium channel complex]
GO:0002027 [regulation of heart rate]
GO:0005216 [ion channel activity]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0007600 [sensory perception]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019228 [neuronal action potential]
GO:0019233 [sensory perception of pain]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0044325 [ion channel binding]
GO:0055085 [transmembrane transport]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060371 [regulation of atrial cardiac muscle cell membrane depolarization]
GO:0070062 [extracellular exosome]
GO:0071439 [clathrin complex]
GO:0086010 [membrane depolarization during action potential]
GO:0086016 [AV node cell action potential]
GO:0086043 [bundle of His cell action potential]
Show all
 1956 aa
220.6 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.