Tissue expression of SCN10A - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SCN10A
Gene description	Sodium channel, voltage gated, type X alpha subunit
Protein class	Disease related genes FDA approved drug targets Plasma proteins Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Not detected
GTEx:	Not detected

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Not detected
GTEx dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	SCN10A (HGNC Symbol)
Synonyms	hPN3, Nav1.8, PN3, SNS
Description	Sodium channel, voltage gated, type X alpha subunit (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	38696802 - 38794010
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185313 (version 83.38)
Entrez gene	6336
UniProt	Q9Y5Y9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5Y9
Antibodypedia	SCN10A antibodies

PROTEIN BROWSER

SCN10A-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCN10A-001 ENSP00000390600 ENST00000449082	Q9Y5Y9 [Direct mapping] Sodium channel protein type 10 subunit alpha Show all	Voltage-gated ion channels Voltage-Gated Sodium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0001518 [voltage-gated sodium channel complex] GO:0002027 [regulation of heart rate] GO:0005216 [ion channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0007600 [sensory perception] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019228 [neuronal action potential] GO:0019233 [sensory perception of pain] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042475 [odontogenesis of dentin-containing tooth] GO:0044325 [ion channel binding] GO:0055085 [transmembrane transport] GO:0055117 [regulation of cardiac muscle contraction] GO:0060371 [regulation of atrial cardiac muscle cell membrane depolarization] GO:0070062 [extracellular exosome] GO:0071439 [clathrin complex] GO:0086010 [membrane depolarization during action potential] GO:0086016 [AV node cell action potential] GO:0086043 [bundle of His cell action potential] Show all	1956 aa 220.6 kDa	No	>9