Cell atlas - CDK10 - The Human Protein Atlas

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CDK10

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Midbody
	Midbody ring
	Nucleoplasm

Human cell
	Microtubules
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CDK10
Gene description	Cyclin-dependent kinase 10
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the midbody & midbody ring.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Midbody (approved), Midbody ring (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA059634 , HPA067060
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the midbody & midbody ring.

Main location

Nucleoplasm (supported)

Additional location

Midbody (approved), Midbody ring (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA059634	HeLa	Nucleoplasm
HPA059634	MCF7	Nucleoplasm
HPA059634	U-2 OS	Nucleoplasm
		Midbody ring	Intensity	Intensity
		Cytosol
HPA067060	HeLa	Nucleoplasm
HPA067060	MCF7	Nucleoplasm
HPA067060	U-2 OS	Nucleoplasm	Intensity
HPA067060	U-2 OS	Midbody	Intensity	Intensity

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Nucleoplasm

GENE INFORMATION
Gene name	CDK10 (HGNC Symbol)
Synonyms	PISSLRE
Description	Cyclin-dependent kinase 10 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	89680737 - 89696364
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185324 (version 83.38)
Entrez gene	8558
UniProt	Q15131 (UniProt - Evidence at protein level)
neXtProt	NX_Q15131
Antibodypedia	CDK10 antibodies

PROTEIN BROWSER

CDK10-001	CDK10-003	CDK10-016	CDK10-022	CDK10-201	CDK10-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDK10-001 ENSP00000338673 ENST00000353379	Q15131 [Direct mapping] Cyclin-dependent kinase 10 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007089 [traversing start control point of mitotic cell cycle] GO:0008285 [negative regulation of cell proliferation] GO:0043410 [positive regulation of MAPK cascade] GO:0097472 [cyclin-dependent protein kinase activity] Show all	360 aa 41 kDa	No	0
CDK10-003 ENSP00000424415 ENST00000505473	Q15131 [Direct mapping] Cyclin-dependent kinase 10 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007089 [traversing start control point of mitotic cell cycle] GO:0008285 [negative regulation of cell proliferation] Show all	272 aa 30.7 kDa	No	0
CDK10-016 ENSP00000329957 ENST00000331006	F8W872 [Direct mapping] Cyclin-dependent kinase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	313 aa 35.6 kDa	No	0
CDK10-022 ENSP00000457055 ENST00000564192	H3BT74 [Direct mapping] Cyclin-dependent kinase 10 Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	239 aa 26.5 kDa	No	0
CDK10-201 ENSP00000484357 ENST00000617879	Q15131 [Direct mapping] Cyclin-dependent kinase 10 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007089 [traversing start control point of mitotic cell cycle] GO:0008285 [negative regulation of cell proliferation] Show all	272 aa 30.7 kDa	No	0
CDK10-202 ENSP00000486594 ENST00000625631	Q9UHL7 [Direct mapping] Cyclin-dependent kinase 10; Cyclin-dependent kinase related protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	42 aa 4.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.