Tissue expression of CDK10 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CDK10
Gene description	Cyclin-dependent kinase 10
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CDK10 (HGNC Symbol)
Synonyms	PISSLRE
Description	Cyclin-dependent kinase 10 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	89680737 - 89696364
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185324 (version 83.38)
Entrez gene	8558
UniProt	Q15131 (UniProt - Evidence at protein level)
neXtProt	NX_Q15131
Antibodypedia	CDK10 antibodies

PROTEIN BROWSER

CDK10-001	CDK10-003	CDK10-016	CDK10-022	CDK10-201	CDK10-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDK10-001 ENSP00000338673 ENST00000353379	Q15131 [Direct mapping] Cyclin-dependent kinase 10 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007089 [traversing start control point of mitotic cell cycle] GO:0008285 [negative regulation of cell proliferation] GO:0043410 [positive regulation of MAPK cascade] GO:0097472 [cyclin-dependent protein kinase activity] Show all	360 aa 41 kDa	No	0
CDK10-003 ENSP00000424415 ENST00000505473	Q15131 [Direct mapping] Cyclin-dependent kinase 10 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007089 [traversing start control point of mitotic cell cycle] GO:0008285 [negative regulation of cell proliferation] Show all	272 aa 30.7 kDa	No	0
CDK10-016 ENSP00000329957 ENST00000331006	F8W872 [Direct mapping] Cyclin-dependent kinase 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	313 aa 35.6 kDa	No	0
CDK10-022 ENSP00000457055 ENST00000564192	H3BT74 [Direct mapping] Cyclin-dependent kinase 10 Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	239 aa 26.5 kDa	No	0
CDK10-201 ENSP00000484357 ENST00000617879	Q15131 [Direct mapping] Cyclin-dependent kinase 10 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004693 [cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0007089 [traversing start control point of mitotic cell cycle] GO:0008285 [negative regulation of cell proliferation] Show all	272 aa 30.7 kDa	No	0
CDK10-202 ENSP00000486594 ENST00000625631	Q9UHL7 [Direct mapping] Cyclin-dependent kinase 10; Cyclin-dependent kinase related protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016301 [kinase activity] GO:0016310 [phosphorylation] Show all	42 aa 4.9 kDa	No	0