Cell atlas - ATP6V0A2 - The Human Protein Atlas

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ATP6V0A2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	ATP6V0A2
Gene description	ATPase, H+ transporting, lysosomal V0 subunit a2
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the plasma membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA044279
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the plasma membrane.

Main location

Cytosol (approved)

Additional location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044279	A-431	Cytosol
	HPA044279	U-2 OS	Cytosol
	HPA044279	U-251 MG	Plasma membrane
			Focal adhesion sites
			Cytosol

GENE INFORMATION
Gene name	ATP6V0A2 (HGNC Symbol)
Synonyms	a2, ATP6a2, ATP6N1D, J6B7, Stv1, TJ6, TJ6M, TJ6s, Vph1
Description	ATPase, H+ transporting, lysosomal V0 subunit a2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome. [provided by RefSeq, Jul 2009]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	123712318 - 123761755
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185344 (version 83.38)
Entrez gene	23545
UniProt	Q9Y487 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y487
Antibodypedia	ATP6V0A2 antibodies

PROTEIN BROWSER

ATP6V0A2-001	ATP6V0A2-003	ATP6V0A2-006	ATP6V0A2-007	ATP6V0A2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP6V0A2-001 ENSP00000332247 ENST00000330342	Q9Y487 [Direct mapping] V-type proton ATPase 116 kDa subunit a isoform 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain] GO:0001669 [acrosomal vesicle] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006879 [cellular iron ion homeostasis] GO:0006955 [immune response] GO:0007035 [vacuolar acidification] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0030670 [phagocytic vesicle membrane] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0051117 [ATPase binding] GO:0055085 [transmembrane transport] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] GO:0090382 [phagosome maturation] Show all	856 aa 98.1 kDa	No	7
ATP6V0A2-003 ENSP00000443441 ENST00000504192	F5H5F3 [Direct mapping] V-type proton ATPase subunit a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0007035 [vacuolar acidification] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0051117 [ATPase binding] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] Show all	328 aa 38.1 kDa	No	1
ATP6V0A2-006 ENSP00000443726 ENST00000534943	F5H847 [Direct mapping] V-type proton ATPase subunit a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0007035 [vacuolar acidification] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0051117 [ATPase binding] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] Show all	131 aa 14.8 kDa	No	3
ATP6V0A2-007 ENSP00000441143 ENST00000544833	F5GX48 [Direct mapping] V-type proton ATPase subunit a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0007035 [vacuolar acidification] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0051117 [ATPase binding] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] Show all	138 aa 15.5 kDa	No	3
ATP6V0A2-201 ENSP00000482236 ENST00000613625	Q8TBM3 [Direct mapping] V-type proton ATPase subunit a Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007035 [vacuolar acidification] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0051117 [ATPase binding] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] Show all	372 aa 43.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.