Expression of HGS in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Hepatocyte growth factor-regulated tyrosine kinase substrate

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA004872	HPA007728

GENE INFORMATION
Gene name	HGS (HGNC Symbol)
Synonyms	Hrs, Vps27, ZFYVE8
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81683326 - 81703138
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185359 (version 83.38)
Entrez gene	9146
UniProt	O14964 (UniProt - Evidence at protein level)
neXtProt	NX_O14964
Antibodypedia	HGS antibodies

PROTEIN BROWSER

HGS-001	HGS-003	HGS-008	HGS-011	HGS-013	HGS-017	HGS-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HGS-001 ENSP00000331201 ENST00000329138	O14964 [Direct mapping] Hepatocyte growth factor-regulated tyrosine kinase substrate Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005829 [cytosol] GO:0006622 [protein targeting to lysosome] GO:0006886 [intracellular protein transport] GO:0006892 [post-Golgi vesicle-mediated transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008285 [negative regulation of cell proliferation] GO:0010324 [membrane invagination] GO:0010628 [positive regulation of gene expression] GO:0016197 [endosomal transport] GO:0019904 [protein domain specific binding] GO:0031901 [early endosome membrane] GO:0032585 [multivesicular body membrane] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042176 [regulation of protein catabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043405 [regulation of MAP kinase activity] GO:0046426 [negative regulation of JAK-STAT cascade] GO:0046872 [metal ion binding] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] GO:0072657 [protein localization to membrane] GO:1903543 [positive regulation of exosomal secretion] Show all	777 aa 86.2 kDa	No	0
HGS-003 ENSP00000459685 ENST00000571518	I3L2H4 [Direct mapping] Hepatocyte growth factor-regulated tyrosine kinase substrate Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	59 aa 7 kDa	No	0
HGS-008 ENSP00000458987 ENST00000572392	I3L1P5 [Direct mapping] Hepatocyte growth factor-regulated tyrosine kinase substrate Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006886 [intracellular protein transport] GO:0043231 [intracellular membrane-bounded organelle] GO:0046872 [metal ion binding] Show all	263 aa 30 kDa	No	0
HGS-011 ENSP00000458603 ENST00000577012	I3L165 [Direct mapping] Hepatocyte growth factor-regulated tyrosine kinase substrate Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0006886 [intracellular protein transport] Show all	71 aa 8.4 kDa	No	0
HGS-013 ENSP00000458775 ENST00000571237	I3L1E3 [Direct mapping] Hepatocyte growth factor-regulated tyrosine kinase substrate Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		292 aa 32.4 kDa	No	0
HGS-017 ENSP00000460130 ENST00000575078	I3L326 [Direct mapping] Hepatocyte growth factor-regulated tyrosine kinase substrate Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 12 kDa	No	0
HGS-018 ENSP00000458789 ENST00000573320	I3L1F1 [Direct mapping] Hepatocyte growth factor-regulated tyrosine kinase substrate Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		63 aa 6.8 kDa	No	0