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HGS

GENERAL INFORMATION

Gene name

 HGS

Gene description

 Hepatocyte growth factor-regulated tyrosine kinase substrate

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression at variable levels in most tissues.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA004872 , HPA007728
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HGS (HGNC Symbol)

Synonyms

 Hrs, Vps27, ZFYVE8

Description

 Hepatocyte growth factor-regulated tyrosine kinase substrate (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 81683326 - 81703138

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185359 (version 83.38)

Entrez gene

 9146

UniProt

 O14964 (UniProt - Evidence at protein level)

neXtProt

 NX_O14964

Antibodypedia

 HGS antibodies

PROTEIN BROWSER
HGS-001
HGS-003
HGS-008
HGS-011
HGS-013
HGS-017
HGS-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HGS-001
ENSP00000331201
ENST00000329138
O14964 [Direct mapping]
Hepatocyte growth factor-regulated tyrosine kinase substrate
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0006622 [protein targeting to lysosome]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008285 [negative regulation of cell proliferation]
GO:0010324 [membrane invagination]
GO:0010628 [positive regulation of gene expression]
GO:0016197 [endosomal transport]
GO:0019904 [protein domain specific binding]
GO:0031901 [early endosome membrane]
GO:0032585 [multivesicular body membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042176 [regulation of protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043405 [regulation of MAP kinase activity]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046872 [metal ion binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0072657 [protein localization to membrane]
GO:1903543 [positive regulation of exosomal secretion]
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 777 aa
86.2 kDa 		No 0
HGS-003
ENSP00000459685
ENST00000571518
I3L2H4 [Direct mapping]
Hepatocyte growth factor-regulated tyrosine kinase substrate
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
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 59 aa
7 kDa 		No 0
HGS-008
ENSP00000458987
ENST00000572392
I3L1P5 [Direct mapping]
Hepatocyte growth factor-regulated tyrosine kinase substrate
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006886 [intracellular protein transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
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 263 aa
30 kDa 		No 0
HGS-011
ENSP00000458603
ENST00000577012
I3L165 [Direct mapping]
Hepatocyte growth factor-regulated tyrosine kinase substrate
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
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 71 aa
8.4 kDa 		No 0
HGS-013
ENSP00000458775
ENST00000571237
I3L1E3 [Direct mapping]
Hepatocyte growth factor-regulated tyrosine kinase substrate
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 292 aa
32.4 kDa 		No 0
HGS-017
ENSP00000460130
ENST00000575078
I3L326 [Direct mapping]
Hepatocyte growth factor-regulated tyrosine kinase substrate
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 110 aa
12 kDa 		No 0
HGS-018
ENSP00000458789
ENST00000573320
I3L1F1 [Direct mapping]
Hepatocyte growth factor-regulated tyrosine kinase substrate
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 63 aa
6.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.