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RNA tissue category: Group enriched (placenta, adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, pituitary gland, ovary)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (pituitary gland, placenta)
GENE INFORMATION
Gene name
DLK1 (HGNC Symbol)
Synonyms
Delta1, FA1, pG2, Pref-1, ZOG
Description
Delta-like 1 homolog (Drosophila) (HGNC Symbol)
Entrez gene summary
This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]
