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The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000790 [nuclear chromatin] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0001503 [ossification] GO:0001701 [in utero embryonic development] GO:0001829 [trophectodermal cell differentiation] GO:0001889 [liver development] GO:0001892 [embryonic placenta development] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0030219 [megakaryocyte differentiation] GO:0030324 [lung development] GO:0032993 [protein-DNA complex] GO:0035035 [histone acetyltransferase binding] GO:0035326 [enhancer binding] GO:0042803 [protein homodimerization activity] GO:0042826 [histone deacetylase binding] GO:0043353 [enucleate erythrocyte differentiation] GO:0043425 [bHLH transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0043923 [positive regulation by host of viral transcription] GO:0044212 [transcription regulatory region DNA binding] GO:0044281 [small molecule metabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048511 [rhythmic process] GO:0048596 [embryonic camera-type eye morphogenesis] GO:0048706 [embryonic skeletal system development] GO:0060136 [embryonic process involved in female pregnancy] GO:0060216 [definitive hemopoiesis] GO:0071837 [HMG box domain binding]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000790 [nuclear chromatin] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001046 [core promoter sequence-specific DNA binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0003677 [DNA binding] GO:0003690 [double-stranded DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008022 [protein C-terminus binding] GO:0008134 [transcription factor binding] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0042803 [protein homodimerization activity] GO:0042826 [histone deacetylase binding] GO:0043425 [bHLH transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0043923 [positive regulation by host of viral transcription] GO:0044212 [transcription regulatory region DNA binding] GO:0044281 [small molecule metabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048511 [rhythmic process] GO:0071837 [HMG box domain binding]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter]