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Most gliomas, ovarian and cervical cancers as well as several endometrial, thyroid and urothelial cancers showed moderate to strong nuclear immunoreactivity. Remaining cancer tissues were mostly negative.
GENE INFORMATION
Gene name
PBX1
Synonyms
Description
Pre-B-cell leukemia homeobox 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001655 [urogenital system development] GO:0001658 [branching involved in ureteric bud morphogenesis] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006694 [steroid biosynthetic process] GO:0007548 [sex differentiation] GO:0008134 [transcription factor binding] GO:0008284 [positive regulation of cell proliferation] GO:0009887 [organ morphogenesis] GO:0009952 [anterior/posterior pattern specification] GO:0009954 [proximal/distal pattern formation] GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle] GO:0030278 [regulation of ossification] GO:0030325 [adrenal gland development] GO:0030326 [embryonic limb morphogenesis] GO:0035019 [somatic stem cell population maintenance] GO:0035162 [embryonic hemopoiesis] GO:0042127 [regulation of cell proliferation] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0045665 [negative regulation of neuron differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048536 [spleen development] GO:0048538 [thymus development] GO:0048568 [embryonic organ development] GO:0048706 [embryonic skeletal system development]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006694 [steroid biosynthetic process] GO:0007548 [sex differentiation] GO:0008134 [transcription factor binding] GO:0035019 [somatic stem cell population maintenance] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006694 [steroid biosynthetic process] GO:0007548 [sex differentiation] GO:0008134 [transcription factor binding] GO:0035019 [somatic stem cell population maintenance] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding]
