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This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0002903 [negative regulation of B cell apoptotic process] GO:0004871 [signal transducer activity] GO:0005158 [insulin receptor binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006006 [glucose metabolic process] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007420 [brain development] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009749 [response to glucose] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0019216 [regulation of lipid metabolic process] GO:0019901 [protein kinase binding] GO:0019903 [protein phosphatase binding] GO:0019904 [protein domain specific binding] GO:0030335 [positive regulation of cell migration] GO:0030879 [mammary gland development] GO:0030890 [positive regulation of B cell proliferation] GO:0032000 [positive regulation of fatty acid beta-oxidation] GO:0032024 [positive regulation of insulin secretion] GO:0032869 [cellular response to insulin stimulus] GO:0033673 [negative regulation of kinase activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043548 [phosphatidylinositol 3-kinase binding] GO:0045087 [innate immune response] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0046326 [positive regulation of glucose import] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0055088 [lipid homeostasis] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0071333 [cellular response to glucose stimulus] GO:0071889 [14-3-3 protein binding] GO:1901653 [cellular response to peptide]
