Expression of ZNRF1 in cancer - Summary

CANCER ATLAS

Gene description

Zinc and ring finger 1, E3 ubiquitin protein ligase

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA027470

GENE INFORMATION
Gene name	ZNRF1 (HGNC Symbol)
Synonyms	DKFZp434E229, FLJ14846, nin283
Description	Zinc and ring finger 1, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary	This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]
Chromosome	16
Cytoband	q23.1
Chromosome location (bp)	74999030 - 75110994
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186187 (version 83.38)
Entrez gene	84937
UniProt	Q8ND25 (UniProt - Evidence at protein level)
neXtProt	NX_Q8ND25
Antibodypedia	ZNRF1 antibodies

PROTEIN BROWSER

ZNRF1-001	ZNRF1-002	ZNRF1-003	ZNRF1-007	ZNRF1-009	ZNRF1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZNRF1-001 ENSP00000323362 ENST00000320619	Q8ND25 [Direct mapping] E3 ubiquitin-protein ligase ZNRF1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016874 [ligase activity] GO:0030054 [cell junction] GO:0030672 [synaptic vesicle membrane] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] GO:0070936 [protein K48-linked ubiquitination] Show all	278 aa 29.8 kDa	No	0
ZNRF1-002 ENSP00000335091 ENST00000335325	Q8ND25 [Direct mapping] E3 ubiquitin-protein ligase ZNRF1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016874 [ligase activity] GO:0030054 [cell junction] GO:0030672 [synaptic vesicle membrane] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] GO:0070936 [protein K48-linked ubiquitination] Show all	227 aa 23.8 kDa	No	0
ZNRF1-003 ENSP00000456168 ENST00000566250	H3BRB6 [Direct mapping] E3 ubiquitin-protein ligase ZNRF1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		209 aa 21.8 kDa	No	0
ZNRF1-007 ENSP00000455601 ENST00000567962	Q8ND25 [Direct mapping] E3 ubiquitin-protein ligase ZNRF1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016874 [ligase activity] GO:0030054 [cell junction] GO:0030672 [synaptic vesicle membrane] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061630 [ubiquitin protein ligase activity] GO:0070936 [protein K48-linked ubiquitination] Show all	227 aa 23.8 kDa	No	0
ZNRF1-009 ENSP00000462910 ENST00000568511	J3KTB9 [Direct mapping] E3 ubiquitin-protein ligase ZNRF1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		52 aa 6 kDa	No	0
ZNRF1-010 ENSP00000457606 ENST00000568351	H3BUF0 [Direct mapping] E3 ubiquitin-protein ligase ZNRF1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.3 kDa	No	0