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ZNRF1

GENERAL INFORMATION

Gene name

 ZNRF1

Gene description

 Zinc and ring finger 1, E3 ubiquitin protein ligase

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA027470
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ZNRF1 (HGNC Symbol)

Synonyms

 DKFZp434E229, FLJ14846, nin283

Description

 Zinc and ring finger 1, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

 This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]

Chromosome

 16

Cytoband

 q23.1

Chromosome location (bp)

 74999030 - 75110994

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186187 (version 83.38)

Entrez gene

 84937

UniProt

 Q8ND25 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8ND25

Antibodypedia

 ZNRF1 antibodies

PROTEIN BROWSER
ZNRF1-001
ZNRF1-002
ZNRF1-003
ZNRF1-007
ZNRF1-009
ZNRF1-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZNRF1-001
ENSP00000323362
ENST00000320619
Q8ND25 [Direct mapping]
E3 ubiquitin-protein ligase ZNRF1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016874 [ligase activity]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
Show all
 278 aa
29.8 kDa 		No 0
ZNRF1-002
ENSP00000335091
ENST00000335325
Q8ND25 [Direct mapping]
E3 ubiquitin-protein ligase ZNRF1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016874 [ligase activity]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
Show all
 227 aa
23.8 kDa 		No 0
ZNRF1-003
ENSP00000456168
ENST00000566250
H3BRB6 [Direct mapping]
E3 ubiquitin-protein ligase ZNRF1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 209 aa
21.8 kDa 		No 0
ZNRF1-007
ENSP00000455601
ENST00000567962
Q8ND25 [Direct mapping]
E3 ubiquitin-protein ligase ZNRF1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016874 [ligase activity]
GO:0030054 [cell junction]
GO:0030672 [synaptic vesicle membrane]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
Show all
 227 aa
23.8 kDa 		No 0
ZNRF1-009
ENSP00000462910
ENST00000568511
J3KTB9 [Direct mapping]
E3 ubiquitin-protein ligase ZNRF1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 52 aa
6 kDa 		No 0
ZNRF1-010
ENSP00000457606
ENST00000568351
H3BUF0 [Direct mapping]
E3 ubiquitin-protein ligase ZNRF1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 78 aa
8.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.