Expression of FFAR4 in cancer - Summary

CANCER ATLAS

Gene description

Free fatty acid receptor 4

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042563

GENE INFORMATION
Gene name	FFAR4 (HGNC Symbol)
Synonyms	GPR120, GPR129, O3FAR1, PGR4
Description	Free fatty acid receptor 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Chromosome	10
Cytoband	q23.33
Chromosome location (bp)	93566665 - 93604480
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186188 (version 83.38)
Entrez gene	338557
UniProt	Q5NUL3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5NUL3
Antibodypedia	FFAR4 antibodies

PROTEIN BROWSER

FFAR4-001	FFAR4-002	FFAR4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FFAR4-001 ENSP00000360536 ENST00000371481	Q5NUL3 [Direct mapping] Free fatty acid receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005504 [fatty acid binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008527 [taste receptor activity] GO:0010827 [regulation of glucose transport] GO:0016021 [integral component of membrane] GO:0043066 [negative regulation of apoptotic process] GO:0046879 [hormone secretion] GO:0050710 [negative regulation of cytokine secretion] GO:0050728 [negative regulation of inflammatory response] GO:0050912 [detection of chemical stimulus involved in sensory perception of taste] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	361 aa 40.5 kDa	No	7
FFAR4-002 ENSP00000360538 ENST00000371483	Q5NUL3 [Direct mapping] Free fatty acid receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005504 [fatty acid binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008527 [taste receptor activity] GO:0010827 [regulation of glucose transport] GO:0016021 [integral component of membrane] GO:0030139 [endocytic vesicle] GO:0043066 [negative regulation of apoptotic process] GO:0045444 [fat cell differentiation] GO:0046879 [hormone secretion] GO:0050710 [negative regulation of cytokine secretion] GO:0050728 [negative regulation of inflammatory response] GO:0050912 [detection of chemical stimulus involved in sensory perception of taste] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	377 aa 42.2 kDa	No	7
FFAR4-003 ENSP00000474477 ENST00000604414	S4R3L2 [Direct mapping] Free fatty acid receptor 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005504 [fatty acid binding] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008527 [taste receptor activity] GO:0016021 [integral component of membrane] GO:0046879 [hormone secretion] GO:0050912 [detection of chemical stimulus involved in sensory perception of taste] Show all	236 aa 25.8 kDa	No	5