Tissue expression of FFAR4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	FFAR4
Gene description	Free fatty acid receptor 4
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (rectum, colon)
GTEx:	Tissue enhanced (pituitary gland)
FANTOM5:	Tissue enriched (pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA042563
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (rectum, colon)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pituitary gland)

GENE INFORMATION
Gene name	FFAR4 (HGNC Symbol)
Synonyms	GPR120, GPR129, O3FAR1, PGR4
Description	Free fatty acid receptor 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Chromosome	10
Cytoband	q23.33
Chromosome location (bp)	93566665 - 93604480
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186188 (version 83.38)
Entrez gene	338557
UniProt	Q5NUL3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5NUL3
Antibodypedia	FFAR4 antibodies

PROTEIN BROWSER

FFAR4-001	FFAR4-002	FFAR4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FFAR4-001 ENSP00000360536 ENST00000371481	Q5NUL3 [Direct mapping] Free fatty acid receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005504 [fatty acid binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008527 [taste receptor activity] GO:0010827 [regulation of glucose transport] GO:0016021 [integral component of membrane] GO:0043066 [negative regulation of apoptotic process] GO:0046879 [hormone secretion] GO:0050710 [negative regulation of cytokine secretion] GO:0050728 [negative regulation of inflammatory response] GO:0050912 [detection of chemical stimulus involved in sensory perception of taste] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	361 aa 40.5 kDa	No	7
FFAR4-002 ENSP00000360538 ENST00000371483	Q5NUL3 [Direct mapping] Free fatty acid receptor 4 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005504 [fatty acid binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008527 [taste receptor activity] GO:0010827 [regulation of glucose transport] GO:0016021 [integral component of membrane] GO:0030139 [endocytic vesicle] GO:0043066 [negative regulation of apoptotic process] GO:0045444 [fat cell differentiation] GO:0046879 [hormone secretion] GO:0050710 [negative regulation of cytokine secretion] GO:0050728 [negative regulation of inflammatory response] GO:0050912 [detection of chemical stimulus involved in sensory perception of taste] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	377 aa 42.2 kDa	No	7
FFAR4-003 ENSP00000474477 ENST00000604414	S4R3L2 [Direct mapping] Free fatty acid receptor 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005504 [fatty acid binding] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008527 [taste receptor activity] GO:0016021 [integral component of membrane] GO:0046879 [hormone secretion] GO:0050912 [detection of chemical stimulus involved in sensory perception of taste] Show all	236 aa 25.8 kDa	No	5