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BACE1

CANCER ATLAS

Gene description

 Beta-site APP-cleaving enzyme 1

Protein class

 Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB016358

GENE INFORMATION

Gene name

 BACE1 (HGNC Symbol)

Synonyms

 BACE

Description

 Beta-site APP-cleaving enzyme 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 117285207 - 117316259

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186318 (version 83.38)

Entrez gene

 23621

UniProt

 P56817 (UniProt - Evidence at protein level)

neXtProt

 NX_P56817

Antibodypedia

 BACE1 antibodies

PROTEIN BROWSER
BACE1-001
BACE1-002
BACE1-003
BACE1-004
BACE1-006
BACE1-007
BACE1-008
BACE1-009
BACE1-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BACE1-001
ENSP00000318585
ENST00000313005
P56817 [Direct mapping]
Beta-secretase 1
A0A024R3D7 [Target identity:100%; Query identity:100%]
Beta-site APP-cleaving enzyme 1, isoform CRA_d
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Aspartic-type peptidases
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0004175 [endopeptidase activity]
GO:0004190 [aspartic-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005770 [late endosome]
GO:0005771 [multivesicular body]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0008233 [peptidase activity]
GO:0008798 [beta-aspartyl-peptidase activity]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019899 [enzyme binding]
GO:0030163 [protein catabolic process]
GO:0030424 [axon]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0044267 [cellular protein metabolic process]
GO:0050435 [beta-amyloid metabolic process]
GO:0070931 [Golgi-associated vesicle lumen]
Show all
 501 aa
55.8 kDa 		Yes 1
BACE1-002
ENSP00000402228
ENST00000428381
P56817 [Direct mapping]
Beta-secretase 1
A0A024R3F9 [Target identity:100%; Query identity:100%]
Beta-site APP-cleaving enzyme 1, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Aspartic-type peptidases
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0004190 [aspartic-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005770 [late endosome]
GO:0005771 [multivesicular body]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0008233 [peptidase activity]
GO:0008798 [beta-aspartyl-peptidase activity]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016021 [integral component of membrane]
GO:0019899 [enzyme binding]
GO:0030163 [protein catabolic process]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0044267 [cellular protein metabolic process]
GO:0050435 [beta-amyloid metabolic process]
GO:0070931 [Golgi-associated vesicle lumen]
Show all
 432 aa
48.2 kDa 		Yes 1
BACE1-003
ENSP00000424536
ENST00000513780
P56817 [Direct mapping]
Beta-secretase 1
A0A024R3E8 [Target identity:100%; Query identity:100%]
Beta-site APP-cleaving enzyme 1, isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Aspartic-type peptidases
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0004190 [aspartic-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005770 [late endosome]
GO:0005771 [multivesicular body]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0008233 [peptidase activity]
GO:0008798 [beta-aspartyl-peptidase activity]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016021 [integral component of membrane]
GO:0019899 [enzyme binding]
GO:0030163 [protein catabolic process]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0044267 [cellular protein metabolic process]
GO:0050435 [beta-amyloid metabolic process]
GO:0070931 [Golgi-associated vesicle lumen]
Show all
 476 aa
52.9 kDa 		Yes 1
BACE1-004
ENSP00000403685
ENST00000445823
P56817 [Direct mapping]
Beta-secretase 1
A0A024R3D5 [Target identity:100%; Query identity:100%]
Beta-site APP-cleaving enzyme 1, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Aspartic-type peptidases
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0004190 [aspartic-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005770 [late endosome]
GO:0005771 [multivesicular body]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0008233 [peptidase activity]
GO:0008798 [beta-aspartyl-peptidase activity]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016021 [integral component of membrane]
GO:0019899 [enzyme binding]
GO:0030163 [protein catabolic process]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0044267 [cellular protein metabolic process]
GO:0050435 [beta-amyloid metabolic process]
GO:0070931 [Golgi-associated vesicle lumen]
Show all
 457 aa
51.1 kDa 		Yes 1
BACE1-006
ENSP00000475405
ENST00000392937
P56817 [Direct mapping]
Beta-secretase 1
B7Z3Z4 [Target identity:100%; Query identity:100%]
Beta-site APP-cleaving enzyme 1, isoform CRA_f; cDNA FLJ54693, highly similar to Beta-secretase 1 (EC 3.4.23.46)
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Aspartic-type peptidases
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0004190 [aspartic-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005770 [late endosome]
GO:0005771 [multivesicular body]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0008233 [peptidase activity]
GO:0008798 [beta-aspartyl-peptidase activity]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016021 [integral component of membrane]
GO:0019899 [enzyme binding]
GO:0030163 [protein catabolic process]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0044267 [cellular protein metabolic process]
GO:0050435 [beta-amyloid metabolic process]
GO:0070931 [Golgi-associated vesicle lumen]
Show all
 401 aa
45 kDa 		No 1
BACE1-007
ENSP00000422461
ENST00000510630
P56817 [Direct mapping]
Beta-secretase 1
B7Z3K2 [Target identity:100%; Query identity:100%]
cDNA FLJ54690, highly similar to Beta-secretase 1 (EC 3.4.23.46)
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Aspartic-type peptidases
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0004190 [aspartic-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005770 [late endosome]
GO:0005771 [multivesicular body]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006509 [membrane protein ectodomain proteolysis]
GO:0008233 [peptidase activity]
GO:0008798 [beta-aspartyl-peptidase activity]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016021 [integral component of membrane]
GO:0019899 [enzyme binding]
GO:0030163 [protein catabolic process]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0044267 [cellular protein metabolic process]
GO:0050435 [beta-amyloid metabolic process]
GO:0070931 [Golgi-associated vesicle lumen]
Show all
 376 aa
42.2 kDa 		No 1
BACE1-008
ENSP00000434486
ENST00000504995
H0YDX0 [Direct mapping]
Beta-secretase 1
Show all
Predicted intracellular proteins
Show all
GO:0004190 [aspartic-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0030163 [protein catabolic process]
Show all
 40 aa
4.8 kDa 		No 0
BACE1-009
ENSP00000475171
ENST00000510915
U3KPS1 [Direct mapping]
Beta-secretase 1
Show all
Predicted intracellular proteins
Show all
GO:0004190 [aspartic-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0030163 [protein catabolic process]
Show all
 51 aa
6.2 kDa 		No 0
BACE1-013
ENSP00000431848
ENST00000528053
E9PJG7 [Direct mapping]
Beta-secretase 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004190 [aspartic-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0016021 [integral component of membrane]
GO:0030163 [protein catabolic process]
Show all
 467 aa
52.1 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.