Cell atlas - BACE1 - The Human Protein Atlas

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BACE1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	BACE1
Gene description	Beta-site APP-cleaving enzyme 1
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. CAB016358
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB016358	A-431	Plasma membrane
	CAB016358	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	BACE1 (HGNC Symbol)
Synonyms	BACE
Description	Beta-site APP-cleaving enzyme 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]
Chromosome	11
Cytoband	q23.3
Chromosome location (bp)	117285207 - 117316259
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000186318 (version 83.38)
Entrez gene	23621
UniProt	P56817 (UniProt - Evidence at protein level)
neXtProt	NX_P56817
Antibodypedia	BACE1 antibodies

PROTEIN BROWSER

BACE1-001	BACE1-002	BACE1-003	BACE1-004	BACE1-006	BACE1-007	BACE1-008	BACE1-009	BACE1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BACE1-001 ENSP00000318585 ENST00000313005	P56817 [Direct mapping] Beta-secretase 1 A0A024R3D7 [Target identity:100%; Query identity:100%] Beta-site APP-cleaving enzyme 1, isoform CRA_d Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0004175 [endopeptidase activity] GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005770 [late endosome] GO:0005771 [multivesicular body] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006509 [membrane protein ectodomain proteolysis] GO:0008233 [peptidase activity] GO:0008798 [beta-aspartyl-peptidase activity] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0030163 [protein catabolic process] GO:0030424 [axon] GO:0030659 [cytoplasmic vesicle membrane] GO:0031410 [cytoplasmic vesicle] GO:0044267 [cellular protein metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0070931 [Golgi-associated vesicle lumen] Show all	501 aa 55.8 kDa	Yes	1
BACE1-002 ENSP00000402228 ENST00000428381	P56817 [Direct mapping] Beta-secretase 1 A0A024R3F9 [Target identity:100%; Query identity:100%] Beta-site APP-cleaving enzyme 1, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005770 [late endosome] GO:0005771 [multivesicular body] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006509 [membrane protein ectodomain proteolysis] GO:0008233 [peptidase activity] GO:0008798 [beta-aspartyl-peptidase activity] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0030163 [protein catabolic process] GO:0030659 [cytoplasmic vesicle membrane] GO:0044267 [cellular protein metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0070931 [Golgi-associated vesicle lumen] Show all	432 aa 48.2 kDa	Yes	1
BACE1-003 ENSP00000424536 ENST00000513780	P56817 [Direct mapping] Beta-secretase 1 A0A024R3E8 [Target identity:100%; Query identity:100%] Beta-site APP-cleaving enzyme 1, isoform CRA_c Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005770 [late endosome] GO:0005771 [multivesicular body] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006509 [membrane protein ectodomain proteolysis] GO:0008233 [peptidase activity] GO:0008798 [beta-aspartyl-peptidase activity] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0030163 [protein catabolic process] GO:0030659 [cytoplasmic vesicle membrane] GO:0044267 [cellular protein metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0070931 [Golgi-associated vesicle lumen] Show all	476 aa 52.9 kDa	Yes	1
BACE1-004 ENSP00000403685 ENST00000445823	P56817 [Direct mapping] Beta-secretase 1 A0A024R3D5 [Target identity:100%; Query identity:100%] Beta-site APP-cleaving enzyme 1, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005770 [late endosome] GO:0005771 [multivesicular body] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006509 [membrane protein ectodomain proteolysis] GO:0008233 [peptidase activity] GO:0008798 [beta-aspartyl-peptidase activity] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0030163 [protein catabolic process] GO:0030659 [cytoplasmic vesicle membrane] GO:0044267 [cellular protein metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0070931 [Golgi-associated vesicle lumen] Show all	457 aa 51.1 kDa	Yes	1
BACE1-006 ENSP00000475405 ENST00000392937	P56817 [Direct mapping] Beta-secretase 1 B7Z3Z4 [Target identity:100%; Query identity:100%] Beta-site APP-cleaving enzyme 1, isoform CRA_f; cDNA FLJ54693, highly similar to Beta-secretase 1 (EC 3.4.23.46) Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005770 [late endosome] GO:0005771 [multivesicular body] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006509 [membrane protein ectodomain proteolysis] GO:0008233 [peptidase activity] GO:0008798 [beta-aspartyl-peptidase activity] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0030163 [protein catabolic process] GO:0030659 [cytoplasmic vesicle membrane] GO:0044267 [cellular protein metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0070931 [Golgi-associated vesicle lumen] Show all	401 aa 45 kDa	No	1
BACE1-007 ENSP00000422461 ENST00000510630	P56817 [Direct mapping] Beta-secretase 1 B7Z3K2 [Target identity:100%; Query identity:100%] cDNA FLJ54690, highly similar to Beta-secretase 1 (EC 3.4.23.46) Show all	Enzymes ENZYME proteins Hydrolases Peptidases Aspartic-type peptidases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0004190 [aspartic-type endopeptidase activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005770 [late endosome] GO:0005771 [multivesicular body] GO:0005788 [endoplasmic reticulum lumen] GO:0005794 [Golgi apparatus] GO:0005802 [trans-Golgi network] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0006509 [membrane protein ectodomain proteolysis] GO:0008233 [peptidase activity] GO:0008798 [beta-aspartyl-peptidase activity] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0030163 [protein catabolic process] GO:0030659 [cytoplasmic vesicle membrane] GO:0044267 [cellular protein metabolic process] GO:0050435 [beta-amyloid metabolic process] GO:0070931 [Golgi-associated vesicle lumen] Show all	376 aa 42.2 kDa	No	1
BACE1-008 ENSP00000434486 ENST00000504995	H0YDX0 [Direct mapping] Beta-secretase 1 Show all	Predicted intracellular proteins Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0030163 [protein catabolic process] Show all	40 aa 4.8 kDa	No	0
BACE1-009 ENSP00000475171 ENST00000510915	U3KPS1 [Direct mapping] Beta-secretase 1 Show all	Predicted intracellular proteins Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0030163 [protein catabolic process] Show all	51 aa 6.2 kDa	No	0
BACE1-013 ENSP00000431848 ENST00000528053	E9PJG7 [Direct mapping] Beta-secretase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] GO:0030163 [protein catabolic process] Show all	467 aa 52.1 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.